The PERFoRM project, an innovation action promoted within the scope of the EU Horizon 2020 program, advocates the use of an Industrie 4.0 compliant system architecture for the seamless reconfiguration of robots and machinery. The system architecture re-uses the innovative results from previous successful R&D projects on distributed control systems domain, such as SOCRADES, IMC-AESOP, GRACE and IDEAS. This paper, after describing the main pillars of the PERFoRM system architecture, focuses on mapping the system architecture into four industrial use cases aiming to validate the system architecture design before its deployment in the real environments. © Springer International Publishing AG 2017.