Traditional approaches for quality control treat the production system as a whole and lack the capability to discriminate among changes at different stages. This means that the large amount of data generated or used in a production system, is not efficiently processed. In this context, the strategy developed by the GO0D MAN project will be able to manage the production in an advanced way, involving Big Data as the key element for an efficient and zero defects manufacturing (ZDM) process. The ultimate goal is to develop a production strategy that can guarantee high quality of products without interfering, actually improving, the production efficiency of the entire system. GO0D MAN is an Innovation Action of Horizon 2020 programme and is based on the results achieved in other European Research Projects developed in recent years, such as GRACE, IDEAS and Self-Learning, which addressed the issue of zero-defect production at feasibility and prototyping level.